What are the ".local" and ".cache" folders and can I delete them?

I noticed that these two folders are taking up a staggering 67 mb of my disk usage, while my whole application is about 27 mb.

Can I just delete these two folders? Are they essential for my application to run properly?

There could be many things there, stuff that we put there (it is using almost no space) and packages that you install with pip --user. It's not safe to delete if you don't know what you are doing.